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Dr. Suman Kumar Samanta

Dr. Suman Kumar Samanta

About

Specialization:
Research interest focus on the molecular characterization of novel antidiabetic and chemopreventive agents and their inert mechanistic action through the cutting-edge molecular biology techniques.

Qualification

BSC (Chemistry) The University of Burdwan, India.

MSC (Chemistry, Organic Special), Ramakrishna Mission Residential College, University of Calcutta, India.

PhD (Biochemistry), CSIR-Indian Institute of Chemical Biology, University of Calcutta, India. (2014)

Personal Interest

Photography

Working Experience

Post Doctoral Associate, School of Medicine, University of Pittsburgh, USA. (August, 2014- November, 2016)

Scientist C, Institute of Advanced Study in Science and Technology, Guwahati, Assam, India. (May, 2017- February, 2020).

CSIR-Pool's Scinetist, Institute of Advanced Study in Science and Technology, Guwahati, Assam, India. (February, 2020- February, 2023).

Associate Professor (Research), Assam down town University, Panikhaiti, Guwahati-06, Assam, India. (March, 2023-till)

Research

PATENTS:

Granted

  1. Process for the isolation of organic compounds useful for the treatment of cancer. US patent. Pub No. US2013/0065932A1; 2013.
  2. Two main component molecules: Mahanine and Mahanimbine (Dehydroxy-Mahanine) from Murraya koenigii for the treat in glioblastoma and cervical carcinoma and Mahanimbine exhibits broad spectrum of anti-cancer. Indian Patent, Application No.690/DEL/2011. Patent no. 352973.
  3. Rice bran oil from the scented rice (Joha) variety rich in ω−6 and ω−3 fatty acid, efficacious to diabetes. Indian Patent, Application No.201831035549. Patent no. 405790.

Filed

  1. Diseases Subtype Irrespective Breast Cancer Regulation Through Dietary Phytochemical Mahanine. Indian Patent, Application No. 201831030091.
  2. A Herbal Composition from Premna Herbacea, useful for prevention of Obesity and Type 2 Diabetes and a method for its Extraction. Application No. 201831046382.
  3. A herbal extract from Lysimachia candida for treatment of obesity and related hyperglycemia and a method for its extraction. Application No.201931019887.

RESEARCH ARTICLES PUBLISHED AS FIRST AUTHOR AND/OR CORRESPONDING AUTHOR

  1. Samanta SK, Sehrawat A, Kim SH, Hahm ER, Shuai Y, Roy R, Pore SK, Singh KB, Christner SM, Beumer JH, Davidson NE, Singh SV. Disease Subtype- Independent Biomarkers of Breast Cancer Chemoprevention by Ayurvedic Medicine Component Withaferin A. JNCI-Journal of the National Cancer Institute; 2016, 109(6), djw293; ISSN: 0027-8874. https://doi.org/10.1093/jnci/djw293. [Impact Factor: 11.82, No. of citation: 31].
  2. Samanta SK, Dutta D, Roy S, Bhattacharya K, Sarkar S, Dasgupta AK, Pal BC, Mandal C, Mandal C. Mahanine, a DNA minor groove binding agent exerts cellular cytotoxicity with involvement of C-7-OH and -NH functional groups. J Med Chem; 2013, 56, 5709-5721. ISSN: 0022-2623. https://doi.org/10.1021/jm400290q. [Impact Factor: 8.04; No. of citation: 42].
  3. Samanta SK, Bhattacharya K, Mandal C, Pal BC. Identification and quantification of the active component quercetin 3-O-rutinoside from Barringtoniaracemosa, targets mitochondrial apoptotic pathway in acute lymphoblastic leukemia. J Asian Nat Prod Res; 2010; 12: 639-48. ISSN: 1028-6020. https://doi.org/10.1080/10286020.2010.489040. [Impact Factor: 1.61; No. of citation: 32].
  4. Samanta SK*, Kandimalla R, Gogoi B, Dutta KN, Choudhury P, Deb PK, Devi R, Pal BC, Talukdar NC. Phytochemical Portfolio and Anticancer Activity of Murraya koenigii and its Primary Active Component, Mahanine. Pharmacological Research; 2018; 129:227-236. ISSN: 1043-6618. https://doi.org/10.1016/j.phrs.2017.11.024. [Impact Factor: 10.33; No. of citation: 35].
  5. Samanta SK, Lee J, Hahm ER, and Singh SV. Peptidyl Prolyl Cis/Trans Isomerase Pin1 Regulates Withaferin A-Mediated Cell Cycle Arrest in Human Breast Cancer Cells. Molecular Carcinogenesis; 2018; 57(7):936-946. ISSN: 0899-1987. https://doi.org/10.1002/mc.22814. [Impact Factor: 5.14; No. of citation:10].
  6. Das M, Kandimalla R, Gogoi B, Dutta KN, Choudhury P, Devi R, Dutta PP, Talukdar NC, Samanta SK*. Mahanine, A dietary phytochemical, represses mammary tumor burden in rat and inhibits subtype regardless breast cancer progression through suppressing self-renewal of breast cancer stem cells. Pharmacological Research; 2019; 146; 104330. ISSN: 1043-6618. https://doi.org/10.1016/j.phrs.2019.104330. [Impact Factor: 10.33; No. of citation:15].
  7. Choudhury P, Dutta KN, Singh A, Malakar D, Pillai M, Talukdar NC, Samanta SK*, Devi R*. Assessment of nutritional value and quantitative analysis of bioactive phytochemicals through targeted LC‐MS/MS method in selected scented and pigmented rice varietals. Journal of Food Science; 2020; 85(6), 1781-1792. ISSN: 0022-1147. https://doi.org/10.1111/1750-3841.15164. [Impact Factor: 3.69; No. of citation:7]
  8. Kandimalla R, Das M, Barge SR, Sarma PP, Koiri DJ, Devi A, Karki AK, Kumar A, Devi R, Pal BC, Talukdar NC, Samanta SK*. Variation in biosynthesis of an effective anticancer secondary metabolite, mahanine in Murraya koenigii, conditional on soil physicochemistry and weather suitability. Sci Rep; 2020; 10(1):20096. ISSN: 2045-2322. https://doi.org/10.1038/s41598-020-77113-y. [Impact Factor: 5.0, No. of citation: 4].
  9. Choudhury P, Dutta KN, Talukdar NC, Samanta SK*, Devi R*. Quantitative analysis of bio-active phytochemical(s) in selected scented rice varieties (Oryza sativa) reveals its intake towards advantage against metabolic disorders. IJTK; 2020. 20 (1), 210-220. ISSN: 0972-5938. http://nopr.niscpr.res.in/handle/123456789/56286. [Impact Factor: 1.09, No. of citation: 2].
  10. Kandimalla R, Das M, Bhattacharjee S, Choudhury P, Devi R, Talukdar NC, Samanta SK*. Effect of multiple doses of N-methyl-N-nitrosourea, an end product of methylguanidine (found in processed food), on the fertility of female Swiss albino mice. Heliyon; 2021. 7(4), e06738. ISSN: 2405-8440. https://doi.org/10.1016/j.heliyon.2021.e06738. [Impact Factor: 3.78, No. of citation: 1].
  11. Samanta SK*, Choudhury P, Sarma PP, Gogoi B, Gogoi N, Devi R. Dietary phytochemicals/nutrients as promising protector of breast cancer development: A comprehensive analysis. Pharmacological Rep; 2022, 1-19. https://doi.org/10.1007/s43440-022-00373-0. [Impact Factor: 3.92, No. of citation: 1].
  12. Choudhury P,  Samanta SK*,  Bhattacharjee S, Sarma H, Devi R. Chemical composite of indigenous whole grain scented joha rice varietal prevents the type 2 diabetes in rats through ameliorating the insulin sensitization by IRS-1/AKT/PI3K/IRS-1/AKT/PI3K signalling cascade, Food Funct., 2022,13, 11879-11895;  ISSN: 2042-650X. https://doi.org/10.1039/D2FO02373C. [Impact Factor: 6.32].
  13. Samanta SK*, Choudhury P, Kandimalla R, Aqil F, Moholkar DN, Gupta RC, Das M, Gogoi B, Gogoi N, Sarma PP, Devi R, Talukdar NC. Mahanine mediated therapeutic inhibition of estrogen receptor-α and CDK4/6 expression, decipher the chemoprevention-signaling cascade in preclinical model of breast cancer, Journal of Ethnopharmacology; 2023, DOI: https://doi.org/10.1016/j.jep.2023.117235.  [Impact Factor: 5.4]
  14. Samanta SK, Talukdar NC. Pharmacological efficacy of Allium hookeri, Premna herbacea and Lysimachia candida in regulating metabolic dysfunctions. ANNALS OF MULTIDISCIPLINARY RESEARCH, INNOVATION AND TECHNOLOGY (AMRIT). 2023. 2(1), 42-49. 
  15. Choudhury P, Gogoi B, Gogoi N, Talukdar NC, Devi R, Samanta SK*. Exploring the Role of Omega-6/Omega-3 Ratio in Disease Management: Insights from Dietary Impact and Molecular Docking Analyses. ANNALS OF MULTIDISCIPLINARY RESEARCH, INNOVATION AND TECHNOLOGY (AMRIT). 2023. 2(2), 1-15. 
  16. Kusza DA, Venter GA, Mabunda M, Biwi J, Samanta SK, Klinck JD, Singh SV, Hunter R,  Kaschula CH. Finding the ajoene sweet-spot: structure-activity relations that govern its blood stability and cancer cytotoxicity. ChemMedChem, 2024; https://doi.org/10.1002/cmdc.202400087. [Impact Factor: 3.4].

RESEARCH ARTICLES PUBLISHED AS CO-AUTHOR

  1. Sehrawat A, Roy R, Pore SK, Hahm ER, Samanta SK, Singh KB, Kim SH, Singh K, Singh SV. Mitochondrial Dysfunction in cancer chemoprevention by phytochemicals from dietary and medicinal plants. Seminars in Cancer Biology; 2017;47:147-153. ISSN: 1044-579X. [Impact Factor: 17.01; No. of citation: 31].
  2. Sarkar S, Dutta D, Samanta SK, Bhattacharya K, Pal BC, Li J, Datta K, Mandal C, Mandal C. Oxidative inhibition of Hsp90 disrupts the super-chaperone complex and attenuates pancreatic adenocarcinoma in vitro and in vivo. Int J Cancer; 2013; 132:695-706. ISSN: 0020-7136. https://doi.org/10.1002/ijc.27687. [Impact Factor: 7.32; No. of citation: 65]
  3. Bhattacharya K, Samanta SK, Tripathi R, Mallick A, Chandra S, Pal BC, Shaha C, Mandal C. Apoptotic effects of mahanine on human leukemic cells are mediated throughcrosstalk between Apo-1/Fas signaling and the Bid protein and via mitochondrial pathways. Biochem Pharmacol; 2010; 79: 361-72. ISSN: 0006-2952. https://doi.org/10.1016/j.bcp.2009.09.007. [Impact Factor: 6.1; No. of citation:97]
  4. Mallick S, Ghosh P, Samanta SK, Kinra S, Pal BC, Gomes A, Vedasiromoni JR. Corchorusin-D, A saikosaponin-like compound isolated from Corchorusacutangulus Lam., targets mitochondrial apoptotic pathways in leukemic cell lines (HL-60 and U937). Cancer Chemother Pharmacol; 2010; 66(4):709-19. ISSN: 0344-5704. https://doi.org/10.1007/s00280-009-1214-3. [Impact Factor: 3.29; No. of citation:24]
  5. Das R, Bhattacharya K, Sarkar S, Samanta SK, Pal BC, Mandal C. Mahanine synergistically enhances cytotoxicity of 5- fluorouracil through ROS-mediated activation of PTEN and p53/p73 incolon carcinoma. Apoptosis; 2014; 19(1):149-64. ISSN: 1360-8185. https://doi.org/10.1007/s10495-013-0907-6. [Impact Factor: 5.56; No. of citation: 42]
  6. Das R, Bhattacharya K, Samanta SK, Pal BC, Mandal C. Improved chemosensitivity in cervical cancer to cisplatin: Synergistic activity of mahanine through STAT3 inhibition. Cancer letters; 2014; 351 (1), 81- 90. ISSN: 0304-3835. https://doi.org/10.1016/j.canlet.2014.05.005. [Impact Factor: 9.76; No. of citation: 56]
  7. Bhattacharya K, Bag AK, Tripathi R, Samanta SK, Pal BC, Shaha C, Mandal C. Mahanine, a novel mitochondrial complex-III inhibitor induces G0/G1 arrest through redox alteration-mediated DNA damage response and regresses glioblastomamultiforme. Am J Cancer Res; 2014; 4(6):629-4. ISSN: 2156-6976. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266700/. [Impact Factor: 5.94; No. of citation: 53]
  8. Kim SH, Hahm ER, Arlotti JA, Samanta SK, Moura MB, Thorne SH, Shuai Y, Anderson CJ, White AG, Lokshin A, Lee J, Singh SV. Withaferin A inhibits in vivo growth of breast cancer cells accelerated by Notch2 knockdown. Breast Cans Res & Treat; 2016; 157 (1), 41-54. ISSN: 0167-6806. https://doi.org/10.1007/s10549-016-3795-y. [Impact Factor: 4.62, No. of citation: 21].
  9. Sarkar Bhattacharya S, Mandal C, Albiez RS, Samanta SK, Mandal C. Mahanine drives pancreatic adenocarcinoma cells into endoplasmic reticular stress-mediated apoptosis through modulating sialylation process and Ca2+-signaling. Sci Rep; 2018; 2; 8(1):3911. ISSN: 2045-2322. https://doi.org/10.1038/s41598-018-22143-w. [Impact Factor: 5.00; No. of citation:9].
  10. Sehrawat A, Samanta SK, Hahm ER, Croix CS, Watkins S, Singh SV. Withaferin A-mediated apoptosis in breast cancer cells is associated with alterations in mitochondrial dynamics. Mitochondrion; 2019; 47, 282-293. ISSN: 1567-7249. https://doi.org/10.1016/j.semcancer.2016.11.009. [Impact Factor: 4.53; No. of citation:31].
  11. Majumder M, Debnath S, Gajbhiye R, Saikia R, Gogoi B, Samanta SK, Das D, Biswas K, Jaisankar P,Mukhopadhyay R. Ricinuscommunis L. fruit extract inhibits migration/invasion, induces apoptosis in breast cancer cells and arrests tumor progression in vivo. Sci Rep; 2019; 9(1):14493. doi: 10.1038/s41598-019-50769-x. ISSN: 2045-2322. https://doi.org/10.1038/s41598-019-50769-x. [Impact Factor: 5.00 No. of citation:32].
  12. Kashyap B, Barge SR, Bharadwaj S, Deka B, Rahman S, Ghosh A, Manna P, Dutta PP, Sheikh Y, Kandimalla R, Samanta SK, et al. Evaluation of therapeutic effect of Premnaherbacea in diabetic rat and isoverbascoside against insulin resistance in L6 muscle cells through bioenergetics and stimulation of JNK and AKT/mTOR signaling cascade. Phytomedicine; 2021; 93, 153761. ISSN: 0944-7113. https://doi.org/10.1016/j.phymed.2021.153761. [Impact Factor: 6.66].
  13. Barge SR,Deka B,Kashyap B, Bharadwaj S, Kandimalla R, Ghosh A, Samanta SK, et al.Astragalin mediates the pharmacological effects of Lysimachia candida Lindl on adipogenesis via downregulating PPARG and FKBP51 signaling cascade. Phytotherapy Research; 2021. 35:6990–7003.ISSN: 0951-418X. https://doi.org/10.1002/ptr.7320. [Impact Factor: 6.39].
  14. Sarma PP, Gurumayum N, Samanta SK, Khound P, Kumari S, Devi D, Barman J, Banerjee SK, Devi R. Pharmacologically active chemical composite of Musa balbisiana ameliorates oxidative stress, mitochondrial cellular respiration, and thereby metabolic dysfunction. Journal of Food Biochem; 2022, 314347, ISSN: 1745-4514. https://doi.org/10.1111/jfbc.14347. [Impact Factor: 3.65].
  15. Kashyap B,  Saikia K, Samanta SK, Thakur D, Banerjee SK,  Borah JC, Talukdar NC. Kaempferol 3-O-rutinoside from Antidesma acidum Retz. Stimulates glucose uptake through SIRT1 induction followed by GLUT4 translocation in skeletal muscle L6 cells, Journal of Ethnopharmacology; 2022, 115788. ISSN: 0378-8741. https://doi.org/10.1016/j.jep.2022.115788. [Impact Factor: 5.2].
  16. Pore SK, Samanta SK, Gogoi B, Hahm ER. Editorial: Phytochemicals in cancer prevention and therapeutics: Current advancement and future perspective. Frontiers in Pharmacol, 14, 495. [Impact Factor: 6.0]

Book Chapter:

  1. Sehrawat A, Samanta SK, Kim SH, Hahm ER, and Singh SV. Scientific Evidence for Anticancer Effects of Withania somnifera and Its Primary Bioactive Component Withaferin A. Science of Ashwagandha: Preventive and Therapeutic Potentials. Springer, 2017. 175-196. 10.1007/978-3-319-59192-6_8.

Conference Publication:

  1. Samanta SK, Singh SV. Pin1 is a novel target of withaferin A, a mammary cancer chemopreventative steroidal lactone from Withania somnifera. Cancer Research 76 (14 Supplement), 2015, 830-830.
  2. Hahm ER, Samanta SK, Sehrawat A, Kim SH, Pore SK, Singh KB, Christner SM, Shuai Y, Beumer JH, Roy R, Davidson NE, Singh SV. Disease subtype independent biomarkers of breast cancer prevention by withaferin a. Cancer Research 77 (13 Supplement), 2016, 5270-5270.
  3. Kandimalla R, Aqil F, Moholkar DN, Samanta SK, Gupta RC. Mahanine, a carbazole alkaloid attenuates lung cancer progression. Cancer Research 82 (12_Supplement), 2022, 707-707.

 

Awards & Achievements

  • Awarded merit Scholarship from National Scholarship Scheme for higher position in HS examination (School Leaving Examination).
  • Awarded as Senior Research Fellow (SRF) from “Council of Scientific and Industrial Research (CSIR)”.
  • Awarded as Senior Research Associate under Scientist Pool’s Scheme from “Council of Scientific and Industrial Research (CSIR)”.
  • Acted as an Editorial member: Frontiers in Pharmacology.
  • Acted as an Invited Reviewer for the following journals: Phytomedicine; Journal of Ethnopharmacology; Frontiers in Pharmacol; All Life; American Journal of Reproductive Immunology; Drug and Chemical Toxicology; Journal of Herbal Medicine; Tissue and Cells; Saudi Pharmaceutical Journal; Journal of Food and Drug Analysis; etc.